Novel pyrrolopyrimidine derivatives: design, synthesis, molecular docking, molecular simulations and biological evaluations as antioxidant and anti-inflammatory agentsArticle Published on 2022-12-012023-07-09 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID19(2023년), [키워드] cytotoxicity DPPH macrophages-RAW 267.4 molecular docking. Pyrrolopyrimidines [DOI] 10.1080/14756366.2022.2090546 PMC 바로가기
Short-term exposure of the mayfly larvae (Cloeon dipterum, Ephemeroptera: Baetidae) to SARS-CoV-2-derived peptides and other emerging pollutants: A new threat for the aquatic environmentsArticle Published on 2022-11-252022-11-15 Journal: The Science of the total environment [Category] SARS, 바이오마커, [키워드] acetylcholinesterase addition ambient aquatic environment aquatic environments Biomarker Biomarkers Cloeon Combination concentrations coronavirus dismutase DPPH ecosystem Effect evaluate evidenced Freshwater ecosystems groups hospital Impact Insects Mortality New coronavirus nitrite Non-target organisms novel novel coronavirus. organism Organisms PCA peptide peptides principal component analysis raised reduced response risk SARS-CoV-2 scavenging significantly lower similarity Spread Stress Topic Treatment viral peptide [DOI] 10.1016/j.scitotenv.2022.157813 PMC 바로가기
Novel hit of DPP-4Is as promising antihyperglycemic agents with dual antioxidant/anti-inflammatory effects for type 2 diabetes with/without COVID-19Research article Published on 2022-11-012022-10-05 Journal: Bioorganic chemistry [Category] SARS, 신약개발, [키워드] activities activity addition Anti-inflammatory antioxidant Cell Co-receptor consequence COVID-19 CRP derivatives DPPH Effect evaluated IL-6 infections molecular docking not correlated novel OGT Patient Pyrimidinones question raised SARS-CoV-2 screened small molecule drug tested therapy Treatment type 2 diabete type 2 diabetes [DOI] 10.1016/j.bioorg.2022.106092 [Article Type] Research article
Phytochemical Analysis, Antimutagenic and Antiviral Activity of Moringa oleifera L. Leaf Infusion: In Vitro and In Silico StudiesMoringa oleifera L. 잎 주입의 식물화학적 분석, 항돌연변이 및 항바이러스 활성: 시험관 내 및 실리코 연구Article Published on 2022-06-222022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activity Analysis analyzed anti-DNA damage antioxidant Antiviral AutoDock binding energy butylated hydroxytoluene carried chromone Compound COVID-19 Deoxyribonucleic acid determine DIPHENYL DNA DPPH Factor FIVE flavonoid flavonoids free radical gallic acid glucoside IC50 in silico in vitro information infusion inhibit Interaction involved kaempferol kelor. LC-MS leaf Liquid chromatography maintain Malnutrition mass spectrometry molecular docking Moringa Moringa oleifera MPro overcome phytochemical Plasmid positive controls Prevent protease PROTECT quercetin SARS-CoV-2 SARS-CoV-2 main protease silico studies silico study the SARS-CoV-2 treated was measured water [DOI] 10.3390/molecules27134017 PMC 바로가기 [Article Type] Article
The chemical constituents of Sterculia comosa (wall) Roxb woods for arginase inhibitory, antioxidant activity, and molecular docking against SARS CoV-2 proteinResearch Article Published on 2022-01-192022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] Sterculia comosa (wall) Roxb. antioxidant arginase binding affinity docking DPPH flavonoid inhibitory inhibitory activity Interaction isolate methanol molecular docking Nsp12 PLPro predicted Protein SARS CoV-2 scavenging spike was determined [DOI] 10.1016/j.heliyon.2022.e08798 PMC 바로가기 [Article Type] Research Article
Promising Antiviral Activity of Agrimonia pilosa Phytochemicals against Severe Acute Respiratory Syndrome Coronavirus 2 Supported with In Vivo Mice StudyArticle Published on 2021-12-162022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] abnormality ABTS activity acute lung injury acute respiratory syndrome addition Adsorption Agrimonia pilosa ALI antioxidant antiviral activity Apoptosis assays caspase-3 caused clinical trials Compound comprehensive analysis conducted coronavirus coronavirus 2 coumarin COVID-19 pandemic disease downregulation DPPH Effect evidenced exhibited expression Gene Expression histopathological IL-18 IL-1β IL-6 immunomodulatory immunomodulatory activity Inflammation investigated LC-ESI-MS/MS lipopolysaccharide LPS lung tissue mechanism of action mice mononuclear cells MPO NF-κB oxidative stress patients with COVID-19 Peripheral blood phytochemical plaque reduction protective effect respiratory SARS-CoV-2 scavenging serum TAC therapeutic compound TLR-4 TNF-α Treatment upregulation virucidal were assessed [DOI] 10.3390/ph14121313 PMC 바로가기 [Article Type] Article
Flavone-Rich Fractions and Extracts from Oroxylum indicum and Their Antibacterial Activities against Clinically Isolated Zoonotic Bacteria and Free Radical Scavenging EffectsArticle Published on 2021-03-222023-05-31 Journal: Molecules [Category] Fulltext, 조류인플루엔자, [키워드] Oroxylum indicum DPPH flavone HPLC mechanism of action scanning electron microscopy zoonotic infection [DOI] 10.3390/molecules26061773 PMC 바로가기 [Article Type] Article
Use of Yoghurt Enhanced with Volatile Plant Oils Encapsulated in Sodium Alginate to Increase the Human Body’s Immunity in the Present Fight Against StressArticle Published on 2020-10-192022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] Adults Against alginate Analysis antimicrobial effect antioxidant antioxidants caused children Compliance component Compound compounds condition control sample cow determine DPPH Effect enhanced Factor food management free radical Free radicals Health healthy highest Human Immunity include increase Initially measure mental health New coronavirus Oil pandemic Pandemics plant present Prevent public health reduction required Romania Safe sodium Spread Stress was determined was obtained was used [DOI] 10.3390/ijerph17207588 PMC 바로가기 [Article Type] Article
Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide TypeArticle Published on 2016-11-282022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] 229E acid Activation activities Alter amide amide bond anticancer Antioxidative antioxidative activity Antiviral antiviral activity binding Biological CAD Cell cell line chloride cinnamic acid derivative Compound compounds Concentration concentrations conjugate Conjugates coronavirus cytostatic activity derivative DPPH evaluated Evidence functional group Hela highest inhibitor inhibitory activity LOX MCF-7 morphology motif novel performed primaquine reducing reported selective spacer synthesis Type [DOI] 10.3390/molecules21121629 PMC 바로가기 [Article Type] Article